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Nitrosamine analytical services

Vitas provides high quality Nitrosamine testing services to the pharmaceutical and nutraceutical industry. Our laboratory is equipped with the most modern instrumentation including UPLC, HPLC, LCMS, LC-MS/MS, LC-TOF-HRMS, GC, GC-MS systems.

DSC_6739-test4.jpg – Vitas Analytical Services

Most nitrosamines (or N-nitrosamines) are organic compounds found to be carcinogenic in animal tests. Nitrosamines are formed by the reaction of nitrite and secondary amines.

Nitrite are mainly used as preservatives and seconday amines mainly arise from the degradation of proteins. Nitrite and nitrosamine intake are associated with risk of gastric cancer and oesophageal cancer. Exposure to nitrosamines are mainly associated with tobacco or dietary exposure. The formation of nitrosamines is shown in figure below.

Figure 1: Formation of nitrosamines from nitrite and secondary amines

Our laboratory, equipped with the most modern instrumentation including UPLC, HPLC, LCMS, LC-MS/MS, LC-TOF-HRMS, GC, GC-MS, ICP-MS systems, is operated by well-trained and highly motivated staff with an average of over 10 years of practical experience. The Pharmaceutical analytical section is GMP-certified and under control of the respective authorities. Vitas holds a manufacturers authorization for medicinal products from the Norwegian Medicinal Agency. We test and analyse medicines and raw materials for most nitrosamines.

Some nitrosamines covered:

  • NDMA (N-nitroso-dimethylamine)

  • NDEA (N-nitroso-diethylamine)

  • NDPA (N-nitroso-dipropylamine)

  • NDiPA (N-nitroso-diisopropylamine)

  • NDBA (N-nitroso-dibutylamine)

  • NEiPA (N-nitroso-ethyl-isopropylamine)

  • NMBA (N-nitroso-methyl-4-aminobutyric acidamine)

We also develop customized nitrosamine analytical services in regards to drug related nitrosamines.

Contact us to find out more about our Nitrosamine Analytical Services

Nitrosamine analysis

Our analytical team

Anders Dahlgren – Vitas Analytical Services

Anders Dahlgren

Chief Technology Officer (CTO)

Anette Sauve – Vitas Analytical Services

Anette Sauve

Head of Pharma Services

Thomas Bjellaas – Vitas Analytical Services

Thomas Bjellaas

Senior Research Scientist

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