Thomas E. Gundersen

Type II diabetes - the silent pandemic

Diabetes is a chronic metabolic disorder characterized by high blood sugar levels. It is a major health problem worldwide and has been called a "silent pandemic" due to its widespread prevalence and impact on public health. Vitas offers the analysis of HbA1c from liquid whole blood, red blood cells, and dried blood spots (DBS). We provide high throughput capabilities compatible with large scale population screening. In addition we offer a set of additional assays to be used in clinical studies and diabetes related research. These include Satiety hormones like PYY, CCK, Ghrelin, Leptin and GLP-1. Also C-peptide and lipids like triacylglycerols (TAG).

The Carotenoids - Natures Rainbow

Carotenoids, vibrant pigments found in plants and fruits, possess remarkable biological functions and play a vital role in nature, human health, and food manufacturing. This article explores their types, functions, chemistry, health benefits, and their significance in food coloring. Carotenoids act as antioxidants, attract pollinators, and provide visual signals in plants. Animals obtain carotenoids from their diet, influencing coloration and providing biological functions. Carotenoids are widely used in the food industry as natural colorants.

Test for Covid-19 on DBS

With support from the Norwegian Research Council, Vitas has developed and validated an IgG serology test for covid-19 in dried blood spots (DBS).

Test for covid-19 antibodies on dried blood spots (DBS)

One newly discovered mutant of the SARS-CoV-2 virus is omicron. The scientific community is working intensely to clarify if the available vaccines protect against omicron, and if the rapid test antigen for the spike 1 protein recognizes the virus and with what sensitivity. Antibodies produced due to omicron infection may also be different from other mutations and undetectable with IgG assays based on the original spike 1 protein.

One million DBS samples received, analyzed and reported

As of December 16, 2021 we have reached an important and noteworthy milestone. One million dried blood spot (DBS) samples have been sent from customers all around the world for analysis of different biomarkers. We currently receive 350 000 DBS samples annually with typical 25 % increase per year, and the rate is increasing from year to year as new customers and new assays are made available.

Lifestyle Intervention Randomized Controlled Trial for Age-Related Macular Degeneration (AMD-Life): Study Design

A nutritional biomarker score of the Mediterranean diet and incident type 2 diabetes: Integrated analysis of data from the MedLey randomised controlled trial and the EPIC-InterAct case-cohort study

Diet-induced Weight Loss and Phenotypic Flexibility Among Healthy Overweight Adults: A Randomized Trial

Associations of circulating C-reactive proteins, APOE ε4, and brain markers for Alzheimer's disease in healthy samples across the lifespan

Plasma Metabolic Signatures of Healthy Overweight Subjects Challenged With an Oral Glucose Tolerance Test

Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis

Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses

Personalised nutrition advice reduces intake of discretionary foods and beverages: findings from the Food4Me randomised controlled trial.

Interactions of Carbohydrate Intake and Physical Activity with Regulatory Genes Affecting Glycaemia: A Food4Me Study Analysis

Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals

Association of plasma biomarkers of fruit and vegetable intake with incident type 2 diabetes: EPIC-InterAct case-cohort study in eight European countries

Characteristics of participants who benefit most from personalised nutrition: findings from the pan-European Food4Me randomised controlled trial

Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations

The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis

Association of plasma vitamin D metabolites with incident type 2 diabetes: EPIC-InterAct case-cohort study

Infant cholesterol and glycated haemoglobin concentrations vary widely-Associations with breastfeeding, infant diet and maternal biomarkers

Association between Diet-Quality Scores, Adiposity, Total Cholesterol and Markers of Nutritional Status in European Adults: Findings from the Food4Me Study

Distribution and determinants of retinol in Norwegian adolescents, and its relation to bone mineral density: the Tromsø Study: Fit Futures

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

Skeletal muscle phosphatidylcholine and phosphatidylethanolamine respond to exercise and influence insulin sensitivity in men

Genetic, dietary, and sex-specifric regulation of hepatic ceramides and relationships between hepatic ceramides and isulin resistance

Combining traditional dietary assessment methods with novel metabolomics techniques: present efforts by the Food Biomarker Alliance

Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study

Vitamin D supplementation and vitamin D status in children of immigrant background in Norway

Within-person reproducibility and sensitivity to dietary change of C15:0 and C17:0 levels in dried blood spots: data from the European Food4Me Study

Biomarkers for nutrient intake with focus on alternative sampling techniques

Vitamin D status in pre-school children in rural Nepalgu

Association Between Prediagnostic Serum 25-Hydroxyvitamin D Concentration and Glioma

Design and baseline characteristics of the Food4Me study: a web-based randomised controlled trial of personalised nutrition in seven European countries

Feasibility of self-sampled dried blood spot and saliva samples sent by mail in a population-based study

Exploring the association of diary product intake with the fatty acids C15:0 and C17:0 measured from dried blood spots in a multi-population cohort: findings from the Food4Me study

Vitamin K2 in different bovine muscles and breeds

Squeezing Sub-Sea Wells Co-Mingled in the Same Flowline on the Norne Field

Omega-3 index and prognosis in acute coronary chest pain petients with a low dietary intake of omega-3

Dried blood spot (DBS) sample collection for determination of the oxidative stress biomarker 8-epi-PGF(2α) in humans using liquid chromatography/tandem mass spectrometry

Cholesterol metabolism: the main pathway acting downstream of cytochrome P450 oxidoreductase in skeletal development of the limb

Determination of 8-epi PGF(2alpha) concentrations as a biomarker of oxidative stress using triple-stage liquid chromatography/tandem mass spectrometry.

Hormone-sensitive lipase (HSL) is also a retinyl ester hydrolase: evidence from mice lacking HSL

25-hydroxyvitamin D in cerebrospinal fluid during relapse and remission of multiple sclerosis

Mechanisms of action of the congenital diaphragmatic hernia-inducing teratogen nitrofen

Quantitative high-throughput determination of endogenous retinoids in human plasma using triple-stage liquid chromatography/tandem mass spectrometry

Reduced serum concentrations of retinol and alpha-tocopherol and high concentrations of hydroperoxides are associated with community levels of S. mansoni infection and schistosomal periportal fibrosis in Ethiopian school children

Simultaneous and trace determination of reduced and oxidized glutathione in minute plasma samples using dual mode fluorescence detection and column switching high performance liquid chromatography

Stability of whole blood and plasma ascorbic acid

Methods for detecting and identifying retinoids in tissue

Simultaneous quantification of reduced and oxidized glutathione in plasma using a two-dimensional chromatographic system with parallel porous graphitized carbon columns coupled with fluorescence and coulometric electrochemical detection

High-throughput analysis of vitamin C in human plasma with the use of HPLC with monolithic column and UV-detection

Biological effects of vitamin K and concentration of vitamin K in Norwegian food

Capillary high-performance liquid chromatographic determination of lutein and zeaxanthin in aqueous humor from a single mouse eye

Identification of novel roles of the cytochrome p450 system in early embryogenesis: effects on vasculogenesis and retinoic Acid homeostasis

Qualitative and quantitative liquid chromatographic determination of natural retinoids in biological samples

Quantitative assessment of retinoid signaling pathways in the developing eye and retina of the chicken embryo

Quantitative axial profiles of retinoic acid in the embryonic mouse spinal cord: 9-cis retinoic acid only detected after all-trans-retinoic acid levels are super-elevated experimentally

Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: important role of retinal dehydrogenase type 2 in synthesis of all-trans-retinoic acid

Evidence for an essential role of megalin in transepithelial transport of retinol

On-line solid-phase extraction and isocratic separation of retinoic acid isomers in microbore column switching system

Temperature-programmed packed capillary liquid chromatography separation with large volume on-column focusing of retinyl esters

Quantitative determination of endogenous retinoids in mouse embryos by high-performance liquid chromatography with on-line solid-phase extraction, column switching and electrochemical detection